Anti-Obesity Sodium Tungstate Treatment Triggers Axonal and Glial Plasticity in Hypothalamic Feeding Centers
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چکیده
منابع مشابه
Anti-Obesity Sodium Tungstate Treatment Triggers Axonal and Glial Plasticity in Hypothalamic Feeding Centers
OBJECTIVE This study aims at exploring the effects of sodium tungstate treatment on hypothalamic plasticity, which is known to have an important role in the control of energy metabolism. METHODS Adult lean and high-fat diet-induced obese mice were orally treated with sodium tungstate. Arcuate and paraventricular nuclei and lateral hypothalamus were separated and subjected to proteomic analysi...
متن کاملVENTROMEDIAL HYPOTHALAMIC NUCLEI AND FEEDING BEHAVIOR
The role of the ventromedial nuclei of the hypothalamus (VMN) in food behavior was studied in adult male rats, allocated in 3 groups: control, sham and lesioned. Electrolytic lesions were induced stereotaxically (1.2 mA, 15 sec). Results revealed a significant decrease (p<O.05) in body weight (BW) and food intake (FI) in the order of lesioned <sham <control during the fIrst week. However, ...
متن کاملSodium tungstate regulates food intake and body weight through activation of the hypothalamic leptin pathway.
AIMS Sodium tungstate is an anti-obesity drug targeting peripheral tissues. In vivo, sodium tungstate reduces body weight gain and food intake through increasing energy expenditure and lipid oxidation, but it also modulates hypothalamic gene expression when orally administered, raising the possibility of a direct effect of sodium tungstate on the central nervous system. METHODS Sodium tungsta...
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The aim of this present work is to study, the corrosion behavior of carbon steel in well water in the presence of sodium tungstate (ST)-Zn 2+ -N-(phosphenomethyl) iminodiaceticacid (NPMIDA) solutions. Electrochemical studies and FTIR spectral studies and weight loss study have been employed. It was found that the inhibition efficiency (IE) of ST (50 ppm)-Zn 2+ (10 ppm) was improved from 8% to 8...
متن کاملGlial Plasticity
Over the last few decades, our understanding of the roles of glial cells in the central nervous system has been transformed. There is now a clear consensus that all classes of glia (astrocytes, oligodendrocytes, microglia, and various other progenitors and specialized cells) can detect and respond to a wide range of neurotransmitters, hormones, cytokines, and trophic factors and thereby play an...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0039087